Analytical Chemistry
Analytical Chemistry provides structural elucidation and physical-chemical characterization of new chemical entities using state-of-the-art instrumentation including Nuclear Magnetic Resonance (NMR) spectroscopy, Fourier transform infrared (FT-IR) spectrophotometry, Fourier transform Raman (FT-Raman) spectroscopy, circular dichroism spectroscopy, polarimetry, x-ray powder pattern analysis, gas chromatography (GC), and GC-mass spectrometry.

GMP Process Pilot Plant
Our state-of-the-art Good Manufacturing Process (GMP) chemical services pilot plant contains kiloliter capacity reactors, filters, dryers and other specialized equipment for preparing multi-kilo batches of Active Pharmaceutical Ingredient (API) to active pharmaceutical ingredient (API) to support Roche Palo Alto clinical studies.

Medicinal Chemistry
Medicinal chemists use a range of traditional and innovative techniques to design and synthesize drug candidates. Lead molecules are developed through high throughput screening or computational methods such as rational drug design, virtual screening, and pharmacophore analysis. Lead optimization employs focused library generation and traditional one-at-a-time synthesis. Compounds are synthesized, purified and characterized using advanced tools such as modern parallel synthesis techniques, LC/mass spectrometry, high field NMR spectroscopy and a variety of chromatographic techniques. To support this critical work, our medicinal chemists have access to extensive internal and external scientific databases, including desktop access to more than 1,000 electronic journals.

3-D Structure Generation
Our capabilities include leading-edge technologies in protein x-ray crystallography, employing modern methods for protein production and high-throughput crystallization condition screening. We have access to beamlines at the Advanced Light Source at the University of California - Berkeley and at the Stanford Synchrotron Radiation Laboratory. Our computational chemists utilize a mix of commercial and proprietary software to enable virtual screening, flexible docking, pharmacophore analysis, and bioinformatics. Application of these tools and technologies increases our efficiency in the lead identification and optimization stages of drug discovery.